A Model of Pre - eclampsia in Rats : The Reduced Uterine Perfusion Pressure 2 ( RUPP ) Model
نویسندگان
چکیده
Ms #H-00117-2012 Revision #2 1 A Model of Pre-eclampsia in Rats: The Reduced Uterine Perfusion Pressure 2 (RUPP) Model 3 4 5 Jing Li , Babbette LaMarca , and Jane F. Reckelhoff 1,2 6 1 Women’s Health Research Center 7 And 8 Department of Physiology and Biophysics 9 and 10 Department of Obstetrics and Gynecology 11 University of Mississippi Medical Center 12 Jackson, MS 13 14 Running Head: Rat Model of Pre-eclampsia 15 16 17 To whom correspondence should be sent: 18 Jane F. Reckelhoff, Ph.D. 19 Department of Physiology and Biophysics 20 University of Mississippi Medical Center 21 2500 N. State Street 22 Jackson, MS 39216-4505 23 Telephone: 601-984-1819 24 FAX: 601-984-1817 25 Email: [email protected] 26 Articles in PresS. Am J Physiol Heart Circ Physiol (April 20, 2012). doi:10.1152/ajpheart.00117.2012
منابع مشابه
17-hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat model.
Preeclampsia is characterized by increased uterine artery resistance index, chronic immune activation, and decreased circulating nitric oxide levels. 17-α-Hydroxyprogesterone caproate (17-OHPC) is a synthetic metabolite of progesterone used for the prevention of recurrent preterm birth. We hypothesized that 17-OHPC could reduce mean arterial pressure by decreasing inflammation, whereas improvin...
متن کاملPlasma-mediated vascular dysfunction in the reduced uterine perfusion pressure model of preeclampsia: a microvascular characterization.
Preeclampsia is associated with widespread maternal vascular dysfunction, which is thought to be mediated by circulating factor(s). The aim of the study was to characterize vascular function in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia and to investigate the role of plasma factors in mediating any observed changes in vascular reactivity. Mean arterial blood pressur...
متن کاملPregnancy/Preeclampsia Plasma-Mediated Vascular Dysfunction in the Reduced Uterine Perfusion Pressure Model of Preeclampsia A Microvascular Characterization
Preeclampsia is associated with widespread maternal vascular dysfunction, which is thought to be mediated by circulating factor(s). The aim of the study was to characterize vascular function in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia and to investigate the role of plasma factors in mediating any observed changes in vascular reactivity. Mean arterial blood pressur...
متن کاملA model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model.
Preeclampsia is defined as new-onset hypertension with proteinuria after 20 wk gestation and is hypothesized to be due to shallow trophoblast invasion in the spiral arteries thus resulting in progressive placental ischemia as the fetus grows. Many animal models have been developed that mimic changes in maternal circulation or immune function associated with preeclampsia. The model of reduced ut...
متن کاملSystemic hemodynamic and regional blood flow changes in response to chronic reductions in uterine perfusion pressure in pregnant rats.
Preeclampsia (PE) is associated with increased total peripheral resistance (TPR), reduced cardiac output (CO), and diminished uterine and placental blood flow. We have developed an animal model that employs chronic reductions in uterine perfusion pressure (RUPP) in pregnant rats to generate a "preeclamptic-like" state during late gestation that is characterized by hypertension, proteinuria, and...
متن کامل